Dr. Lee Ann Sporn

Year Started at Paul Smith’s: 2003
Department: Natural Science
Program: Biology

Interests and Activities

Development of non-invasive methods for molecular analyses of environmental samples and wildlife samples. Painting.

Academic Background

PhD, Toxicology, Univerrsity of Rochester BS, Biology/ Biochemistry, University of Rochester

Publications

2000       Rui-Jin Shia, Patricia J. Simpson-Haidarisa, Victor J. Mardera, David J. Silverman and Lee Ann Sporn. Post-transcriptional regulation of endothelial cell plasminogen activator inhibitor-1 expression during R. rickettsii infection. Microbial Pathogenesis 28:127-133. 2000       Sahni, A., Baker C.A., Sporn L.A., Francis, C.W. Fibrinogen and fibrin protect fibroblast growth factor-2 from proteolytic degradation. Thrombosis and haemostasis 83: 736-741. 1999       Abha Sahni, Lee Ann Sporn and Charles W. Francis. Potentiation of Endothelial Cell Proliferation by Fibrin(ogen)-bound Fibroblast Growth Factor-2. The Journal of Biological Chemistry, 274, 14936-14941. 1999       Sanjeev K. Sahni, Loel C. Turpin, Tracy L. Brown, and Lee Ann Sporn. Involvement of Protein Kinase C in Rickettsia rickettsii-Induced Transcriptional Activation of the Host Endothelial Cell. Infection and Immunity 67: 6418-6423 1998       Lee Ann Sporn, Victor J. Marder and Denisa D. Wagner. Inducible secretion of large, biologically potent von Willebrand factor multimers. Cell 46:185-190. 1998       Dawn R. Clifton, Rachel A. Goss, Sanjeev K. Sahni, Daniel van Antwerp, Raymond B. Baggs, Victor J. Marder, David J. Silverman, and Lee Ann Sporn. NF-κB-dependent inhibition of apoptosis is essential for host cell survival during Rickettsia rickettsii infection , Proceedings of the National Academy of Sciences 95:4646-4651 1998       Rui-Jin Shi, Patricia J. Simpson-Haidaris, Norma B. Lerner, Victor J. Marder, David J. Silverman, and Lee Ann Sporn. Transcriptional Regulation of Endothelial Cell Tissue Factor Expression during Rickettsia rickettsii Infection: Involvement of the Transcription Factor NF-B. Infection and Immunity 66: 1070-1075. 1998       Sanjeev K. Sahni, Daniel J. Van Antwerp, Marina E. Eremeeva, David J. Silverman, Victor J. Marder, and Lee Ann Sporn. Proteasome-Independent Activation of Nuclear Factor B in Cytoplasmic Extracts from Human Endothelial Cells by Rickettsia rickettsii. Infection and Immunity 66: 1827-1833. 1997       G Guadiz, LA Sporn, RA Goss, SO Lawrence, VJ Marder and PJ Simpson-Haidaris. Polarized secretion of fibrinogen by lung epithelial cells. American Journal of Cell and Respiratory Biology 17: 60-69. 1997       Gayle Guadiz, Lee Ann Sporn, and Patricia J. Simpson-Haidaris. Thrombin Cleavage-Independent Deposition of Fibrinogen in Extracellular Matrices. Blood 90: 2644-2653. 1997       LA Sporn, SK Sahni, NB Lerner, VJ Marder, DJ Silverman, LC Turpin and AL Schwab. Rickettsia rickettsii infection of cultured human endothelial cells induces NF-kappaB activation. Infection and Immunity 65: 2786-2791. 1997       Mohammad F. Kiani, Bruce M. Fenton, Lee Ann Sporn and Dietmar W. Siemann. Effects of ionizing radiation on the adhesive interaction of human tumor and endothelial cells in vitro. Clinical and Experimental Metastasis 15: 12-18. 1996       Tatjana M. Odrljin; Charles W. Francis; Lee Ann Sporn; Leslie A. Bunce; Victor J. Marder; Patricia J. Simpson-Haidaris. Heparin-Binding Domain of Fibrin Mediates Its Binding to Endothelial Cells. Arteriosclerosis, Thrombosis, and Vascular Biology 16:1544-1551. 1996       LA Sporn and VJ Marder. Interleukin-1 alpha production during Rickettsia rickettsii infection of cultured endothelial cells: potential role in autocrine cell stimulation. Infection and Immunity 64: 1609-1613. 1996       MA Courtney, PJ Haidaris, VJ Marder and LA Sporn. Tissue factor mRNA expression in the endothelium of an intact umbilical vein. Blood 87: 174-179. 1996       Shi RJ, Simpson-Haidaris PJ, Marder VJ, Silverman DJ, Sporn LA. Increased expression of plasminogen activator inhibitor-1 in R. rickettsii-infected endothelial cells. 1: Thromb Haemost. 75: 600-6. 1995       LA Sporn, LA Bunce and CW Francis. Cell proliferation on fibrin: modulation by fibrinopeptide cleavage. Blood 86: 1802-1810. 1994       LA Sporn, PJ Haidaris, RJ Shi, Y Nemerson, DJ Silverman and VJ Marder. Rickettsia rickettsii infection of cultured human endothelial cells induces tissue factor expression. Blood 83: 1527-1534. 1994       M Hamaguchi, LA Bunce, LA Sporn and CW Francis. Plasmic degradation of fibrin rapidly decreases platelet adhesion and spreading. Blood 84: 1143-1150. 1993       LA Sporn, SO Lawrence, DJ Silverman and VJ Marder. E-selectin-dependent neutrophil adhesion to Rickettsia rickettsii- infected endothelial cells. Blood 81: 2406-2412. 1993       M Hamaguchi, LA Bunce, LA Sporn and CW Francis. Spreading of platelets on fibrin is mediated by the amino terminus of the beta chain including peptide beta 15-42. Blood 81: 2348-2356. 1992       Lee Ann Sporn and Thomas H. Foster. Photofrin and Light Induces Microtubule Depolymerization in Cultured Human Endothelial Cells. Cancer Research 52, 3443-3448. 1991       Thomas H. Foster2, Melissa C. Primavera, Victor J. Marder, Russell Hilf and Lee Ann Sporn. Photosensitized Release of von Willebrand Factor from Cultured Human Endothelial Cells. Cancer Research 51: 3261-3266. 1991       LA Sporn, RJ Shi, SO Lawrence, DJ Silverman and VJ Marder. Rickettsia rickettsii infection of cultured endothelial cells induces release of large von Willebrand factor multimers from Weibel-Palade bodies. Blood 78: 2595-2602. 1990       JH Peters, LA Sporn, MH Ginsberg and DD Wagner. Human endothelial cells synthesize, process, and secrete fibronectin molecules bearing an alternatively spliced type III homology (ED1). Blood 75: 1801-1808. 1989       LA Sporn, VJ Marder and DD Wagner. Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells. The Journal of Cell Biology 108: 1283-1289. 1989       PJ Haidaris, CW Francis, LA Sporn, DS Arvan, FA Collichio and VJ Marder. Megakaryocyte and hepatocyte origins of human fibrinogen biosynthesis exhibit hepatocyte-specific expression of gamma chain-variant polypeptides. Blood 74: 743-750. 1987       D D Wagner, P J Fay, L A Sporn, S Sinha, S O Lawrence, and V J Marder. Divergent fates of von Willebrand factor and its propolypeptide (von Willebrand antigen II) after secretion from endothelial cells. Proceedings of the National Academy of Sciences 84: 1955-1959. 1987       LA Sporn, VJ Marder and DD Wagner. von Willebrand factor released from Weibel-Palade bodies binds more avidly to extracellular matrix than that secreted constitutively. Blood 69: 1531-1534. 1986       Lee Ann Sporn, Victor J. Marder, and Denisa D. Wagner. Inducible secretion of large, biologically potent von Willebrand factor multimers. Cell 46:185 – 190. 1985       Lee Ann Sporn, Stephen 1. Chavin, Victor J. Marder, and Denisa D. Wagner. Biosynthesis of von Willebrand Protein by Human Megakaryocytes. J. Clin. Invest. 76: 1102-1106. 1984       LA Sporn, P Rubin, VJ Marder and DD Wagner. Irradiation induces release of von Willebrand protein from endothelial cells in culture. Blood 64: 567-570.